As far as I know, the latest Detonators (
28.32) should be very stable.. If those dont work, you may want to check inside your computer and see if there is a heat issue. Programs can lock under heavy load due to heat.
Another problem could be bad ram. I made the mistake of purchasing cheap ram, and it would lock my computer all the time, and at random times. If you just put a new stick in recently, try pulling it. Or if you can, try with another stick of ram from a different system.
Crucial tends to have the best ram if your looking for new stuff
The other thing could be the game itself. Does it just happen in one game? or multiple OpenGL games?