Skoorb,
I'm not sure I really understand your question. Maybe this will answer it.
The way to set up your subwoofer really depends on your receiver.
If it's a Dolby Digital receiver, then it has the correct crossover settings and controls to handle the bass. You will set your front speakers to "Small" and tell the receiver that you have a subwoofer, which you will hook up to the RCA subwoofer output. All of the deep bass (it depends on the receiver for the exact cutoff point, but usually anything less than some point between 120Hz and 80Hz) will be sent to the sub, and none will be sent to the Titans. (well, it doesn't 'cut it off' exactly, but it rolls it off very steeply. effectively, it cuts it off.)
If it's a non-DD receiver, then it probably doesn't have adequate bass management, in which case you'll want to run the L/R speaker wire from the receiver to the speaker-level inputs on the sub. Then run the speaker-level outputs on the sub to the Titans. The sub will subtract the low frequencies from the speaker-level signal (and play them), then send the signal on to the speakers. Most subs have a crossover knob so you can set exactly the right point to mix between the sub and satellites. In this case, your receiver will think that it's just driving a normal pair of full-range speakers, but your subwoofer will be fooling it.
Once you have set up the sub, you'll probably want to keep the bass knob on your receiver to its neutral position. However, what you do with this can vary considerably, even with the same set of speakers and just moving them to a different room. Just set it to however it sounds best to you. Unless you want to buy a test-tone CD and an SPL meter, and sit there and graph things and tweak until your graph is flat as possible
Really, that's something that I think most audio people tend to forget about: the most important thing is how it sounds to YOU. We all have an idea that flatter is better, and in an absolute sense, it is. However, our ears and our brains are not absolute. if you really have a preference for deep bass, then by all means turn it up to your heart's content.
FYI many radio stations bump up the bass on their signals to make them sound "better"!