I've spent a fair amount of time in Vegas on business trips. My employer at that time didn't want to spend much on hotels. I've stayed at all ends of the strip and this is my opinion...
Where I stay usually doesn't matter to me. It's where I can get on foot that matters, because when I go to Vegas I want to drink, gamble a little and see things -- all while drinking. So I usually end up walking around at night.
If you stay downtown, it doesn't matter where, because everything is centrally located.
If you stay on the north side of the strip, Circus Circus, you're pretty much out there on your own. You'll have to drive, take the bus or take a taxi to get somewhere. I don't like to stay on the north side of the strip.
Now the south side is a much different story. The hotels are closer together, they have transportation between them (trains/foot bridges) and the streets have bridges so you don't have to mess with traffic. I love staying at Excalibur and from there I can usually walk to anything I want to see. And, IMHO, the best hotels to see are down there, so it's perfect.
Enjoy your trip!
