Well I know of to ways of doing this.
The first is to select a e-mail from a sender you do not want to receive email from any more then go to Message > Block sender.
The other way, which is more advanced, is to go to Tools > Message Rules > Mail and configure different mail 'rules' you want to set up.
If you need help, press F1 and click the "Search' tab and type in 'Mail Rules'
Good Luck!