for plinking at the range and terrorizing tin cans, you can't beat a simple .22 for accuracy, consistancy, and low cost for ammo. There are several styles of Brownings and Rugers that are very decent pistols and will cost less then $300.
Simple and very safe pistols are revolvers; if you want more then a .22, consider a 357; you can shoot 38 or 38 specials, still relatively inexpenive ammo and usually pretty accurate (if you go with adjustable sights). A Ruger 101 will run about $379 and a Taurus will be in the same ball park. This will give you a good "range" pistol, a decent hunting pistol (keep your distance less then 40 yards), and probably the best home style pistol.
If you like auto's, you can get Rugers, Taurus's and a host of used pistols for less then $400.
As was mentioned before, you're best choice is to find a range or a friend who has pistols you can shoot, then see what you like. Really look at your primary purpose/use of the pistol, and remember that you are looking for a pistol that you can use to learn about shooting a pistol safely and to enjoy. At this point in time definetly stay away from the 44's and maybe even the 45's.
Just take it slow and safe.