#1 I thought was easy...I'd pick being mute. If I still had hearing, I could still listen to people, music, etc. If I could still see, I could still watch videos, see the world, etc. I can always use sign language to talk to a few people if I learned it, or try alternate methods of communication.
#2 was extremely difficult for me. I really care about a good portion of my immediate family, which makes it hard for me to have them killed over people I know nothing about. That would mean about 6000 people, in my case. Only problem is, I am disrupting the lives of thousands more who were connected with those 6000 people. The only thing that is making me choose the choice that I have, is the feeling that my own personal pain must surely be greater than what others would go through, even though rationally I understand this would not be the case.
#3 was slightly difficult, but in the end I chose to lose both my arms. Being immobilized would just anger me to no end. Yes, there are wheelchairs, but no, that would not be enough for me. Sure, I can no longer work, but I wouldn't be able to anyway with the loss of two legs and one arm. I couldn't use the computer, but you'd have a rough time using it to its fullest ability with one arm anyway. Sure, web browsing may be easy, and typing may be do-able, but that's about it. And, what about gaming? You can't game with one arm, so might as well cut off the other and keep my mobility. Heck, at least I can still play soccer or something.