No less an authority than John Carmack of id Software has claimed the Linux gaming market is not viable (by any stretch of the imagination).
No major gaming producer is going to target native games for Linux (you'll see a few games occasionally). So face it, either you're satisfied with WineX, willing to keep Winblows for gaming, or you buy a PS2.
In the long run, I don't know how strategic wine is, but they have produced a pretty good product so far. My hunch is that (besides gaming) if people aren't interested in running MS Office under wine, then there's no other reason for wine to be a major factor.
Don't get me wrong, I think wine is a great project. However, in the grand scheme of things, there's a lot more stake in Mozilla becoming popular (for various reasons), for example.