Linux is Linux.
Some distro's have taken it upon themselves to try and appeal to the masses, re desktop market, while others are just as happy remaining a predominantly geek OS.
Mandrake has risen to the challenge, taking on the #1 nightmare, initial install and config.
I've played with Slack, Debian, RH and Mandrake.
If I'm running a server it'll be Slack or Deb, desktop RH or Mandrake.
The thing to remember is that at their cores they are all Linux.