Shouldn't be a problem. I run the Skyrim HD texture pack (not the official DLC one, but the real HD mod-community made ones) along with a bunch of other mods (Static mesh replacer etc, I'm at around 50 mods atm) on a Q9450 @ 3.6ghz 8gb ram w/a 1gb GTX 285. If you're talking about the official DLC texture pack, then definitely not an issue, it's lower res than the mod community made one.