every drug there is.
i would have to say the most "poisoned" i ever felt though, even though it's perfectly safe would have to be hallucinogenic mushrooms... holy god, i blended up a quarter ounce (7 grams) dried very potent mushrooms in orange juice... that was the last time i ever used mushrooms, i was completely mind fuc#ked, couldnt think, everything was a hallucination, i felt like a dried up, burnt piece of bacon frying on a grill.. i kept thinking i had crapped myself for some reason even though i hadn't (wtf) i ended up naked, screaming in broken spanish, in the kitchen of our house, and then eventually started having a TERRIBLE trip, that ego loss feeling, i thought i had messed up my brain, thought i would never be normal again... i eventually just curled up in the fetal position in my bed and completely FREAKED OUT. i was still kind of tripping the next day even, it was a 12 plus hour ordeal.
and i was an experienced drug user to say the least.. i had just never played with anything REALLY REALLY hallucinogenic like that...closest i had come before that was robotripping (dextromethorphan)