Jiggz is one smart kid
To add to his post.. If you ever used SmartDrive (smartdrv) under Dos, you know that by disabling the write-cache your system becomes very slow. Windows' read- and write-caches seem pretty efficient, so disabling those will give you an even bigger slowdown.
With SmartDrive, it wouldn't even let you Ctrl+Alt+Del the PC if its cache wasn't written yet: it would just display a message "Flushing the cache...", and only after the flush would it restart the PC.
Don't forget that the drive cache is used even when working with the Swap file, so when you run out of physical memory everything will seem much slower for ya.