So simple route would be 4 fans going in two fans going out?
Let’s assume the power supply is in its own compartment and fans all move same amount of air.
There's the thing, "assume". In general that sounds right (except few cases have mounts for 4 intake unless some use smaller less restrictive filters) but in a specific case and particular fans, you have to check this or else overshoot enough that you may end up with more noise.
I am not a fan (pun intended) of just throwing more fans at things. Case with 5+ fan mounts strike me as silly unless it's for bitcoin mining or dual card gaming.
I am a fan of throttling back any case exhaust fans besides the PSU fan ( which should do it's own thing assuming a competently designed PSU with a thermal sensor for fan control), and letting filtered intake fans push the air.
Then again, some will prefer to just open their case and inspect and clean it, out of paranoid I suppose or whatever, it was a thing back when motherboards were prone to capacitor rot and you wanted to see if any were bulging but these days not so much.
At the risk of sounding carcinogenic, you can test case positive/negative pressure with cigar smoke. At the same time even if the case is only slightly negatively pressurized, that reduces the amount of dust drawn in. Suppose 1/3rd as much dust is drawn in, then it follows that 3X more time passes before cleaning is needed. With any case, budget, amount of time spent, there could be some compromise.
At the same time, if you have front intake fans through a filter, instead of rear exhaust fans, the hole where a rear exhaust fan would be, is still were the air is exiting if the case doesn't have excessive open holes/slits/gaps/etc, but even if it does have other escape areas, if positively pressurized the air was filtered.
You have to assess it on a case by case basis.