I'd be happy if they'd fix the issues with the current one and call it a Galaxy Nexus II.
IE:
Screen: Current one has the annoying screen door effect, and a bit of image retention, plus it doesn't do well with dark colors (purple hue)
Cellular radio: I seem to get worse signal reception than my other T-mo friends, in the exact same areas.
Speaker: Damn thing is as quiet as a mouse. If I'm at work I can't hear the notifications go off in my pocket, that's annoying.
Camera: I don't take a lot of pictures with my Nexus, but I sure would like it to be similar in quality to say an iPhone 4S, that's a good benchmark.
Battery Life: This just goes for battery tech in general, we need some new discovery that segment has been pretty stagnant for a while, cram a 5000 mAh battery in there without increasing thickness would be awesome.
Either way, I'm still buying it when it comes out in Nov-Dec, at I would imagine the 399 price point, maybe even lower this time.