What I did was created a batch file that (in this order):
1) Runs windows disk cleaner.
2) Defrags all my drives/partitions
3) Runs Adware auto-update.
4) Runs adware.
5) Runs spybot update.
6) Runs spybot.
I run this batch file about once a week. I also use Tweak XP about 1 every month and defrag the boot partition, rearrange boot files, Ect. Also, on a side not I use driver cleaner 3.1 when I'm uninstalling and reinstalling drivers (just to make sure no more pesky files are left behind).