I bought this case thinking it would be similar to the Antec 1080s that I have...but was disappointed. No latching case door. The door on this case interferes with the DVD drive button...so you actually have to mount the drive recessed so it doesn't push the button when you close the door. I also didn't care for the old-fashioned method of attaching optical drives to the case (with drive rails).
That said, the case *should* fit a 10.5" video card, since it's EXACTLY 10.5" from the card mounting surface at the back of the case to the rolled front lip of the HDD mounting rack. The rolled lip is about 3/8" deep, so once the card is past that, it will have 3/8" clearance at the end (I hope that makes sense).