Possibly. G Skill has a ram finder tool on their website where it will tell you what RAM they manufacture that will work properly on a particular motherboard.
If a person doesn't use RAM that is guaranteed to work properly by the manufacturer (either the motherboard or RAM manufacturer), they wouldn't know for sure until they installed it and tested it out. I call that the "plug and pray" approach.
Yeah -- that's a good one.
Generally, from my humble and limited experience, a RAM kit may show dual-dual/quad compatibility with two chipsets. I had seen G.SKILLs that would work in either Z170 or X99. It seemed to me that none of those kits had the best timings for Z170, though. I bought the RAM at the speed I wanted and the lowest timings.
Sometimes, from the model-code common to any and all item-resellers and their description page, you can determine which models likely use same or similar "black-parts" from an alpha string in the code. As an example, I bought G.SKILL 1600's 9-9-9 XMP for my 2600K five years ago, and the code ended in the string "-GBRL." These were RipJaws; there were other Ripjaws variations -- including "X" and "Z" for which model-code ended in a different string. You could find -GBRL kits in various speed specs: 1,333, 1600, 1866. If they went higher, I never found any.
So the QVL list of the motherboard manufacturer may have shown a 1333 kit that was "GBRL" as compatible, and if the motherboard included RAM "(OC)" specs, you would see that some 1600's or 1866's would work. For those DDR3 kits especially, we - I -- found that you could OC the 1600's to 1866 by loosening the first three timings by 1, and probably the fourth timing by 6.
Sometimes, the RAM-maker -- like G.SKILL -- will have a configurator which shows they only tested certain board models and that yours, which is part of the same model-line, isn't included. Well -- look at the specs to the next higher or lower model. Or both. If they turn up certain models that fill your bill and float your boat for speed and timings, using those models may be fairly certain of success.
If there's any "Plug-and-Pray" after that, you have 30 days depending on where you bought them, but with that kind of investigation to turn up a model you would like for your board, not likely to happen.
Put it another way. If your X99 chipset is implicitly compatible with a 2x kit that otherwise operates as dual-channel, you should be able to use two kits and use them in quad-channel configuration.