Originally posted by: gsethi
Middle seat...that Apple ad comes to mind
Personally, I always take the Window seat. Something to look at (time passes) and a wall as your headrest. Even at night, you can still see lights etc. (if flying over land) or the movements of the wing etc.
You can always tell the person in middle/aisle to stand when you have to go to restroom. If they sleeping, tell them that your other option is to pee on them

(joking)
Seriously, in my West coast <-> East Coast flights, I only get up once in the middle of the flight (~6hrs). So trans-atlantic, max I will be getting up is ~2 times which is not annoying to anyone.
Yes, aisle is good b/c you can get up anytime and stretch without asking someone