Yes. DMA mode transfers are essential to a computer's performance. If they're not enabled, any hard disk activity immediately takes up to 90% of your CPU time. Practical impact on performance is very evident, in any heavier-duty gaming you're bound to see lots of stuttering and you won't be able to play DVD movies smoothly if DMA mode transfers are disabled. DMA mode can cause data loss on systems with PCI bus overclocked at 40MHz'ish range, but if your system is configured properly (if everything else is functioning, it propably is) and is running at default clock, there should be no danger.