Slot inserts? I don't know what you mean, the commercial parts you buy are done with heat and grooved inserts, like glue lines in a dowel.
I have not done this for an insert but have tapped plexi for use in reservoirs. I would use the same method I use in wood cabinets just more care and certainly a few test runs would be in order. I like brass inserts
like these with a wood screw thread. The inserts I use for a 6-32 screw have the same thread as a #14 wood screw. First I make a tap from a 2 or 3" screw. I cut the head off a to fit in a drill, (a
very slow VSR battery drill is best) cut two slots in the threads with a dremel to do the cutting, parallel to the shank angled off the center-line to create teeth that will cut. Finally I'll grind the point off to cut threads to the bottom of a stopped hole. Be sure to use soap or wax and back it all the way out to clear the tap as the cut plastic will damage the threads you've just cut. Buy or make a tool to run these. Using just a standard screwdriver is asking for trouble.
edit- Never saw those before, good find daw