Thank you for all your replies to my inquiry everyone. Given the information you provided, I now have a reference to a threadripper ATX vs E-ATX board I just noticed that the E-ATX mobos simply just extend off the last ATX mounting screw hole. This resolved a misunderstanding I had that was confusing me w.r.t to thinking E-ATX had another screw hole on the extended part. I'll be able to confirm case compatibility with the information you guys provided

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One obvious issue w/ the yuge socket size and board size restrictions is that manufacturers are getting creative with the layout.
One thing that also caught me eye is different PCI-E slot layouts. In the case of this threadripper board, is this spacing setup for 4 videocards that take up 2 slots each? If this route is taken, would the stubby pci-e port in black be blocked by the GPU? Do people use pci-e riser cables in situations where the slots are blocked by double with cards?
In the case of the Gigabyte board :
Completely different spacing of the pci-e slots .... Single slot spacing is nestled in between two double slots. Given the spacing between the vidya card slots, would you just use a longer sli cable? Like so (but longer)? :
In the case of 4 GPUs, it appears the 3rd pci-e slot would be blocked? Again, can a riser cable be used to access this?
All of the board seems to carry 2-3 M.2 slots and get creative w.r.t to soaking up the number of PCI-E ports made available by the socket.