THC exposure alters brain maximal oxidative capacity. (Thoughts and opinions please)...

IGBT

Lifer
Jul 16, 2001
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THC exposure alters brain maximal oxidative capacity. It impairs mainly the complexes I, II, and III of the mitochondrial respiratory chain and mitochondrial coupling. THC also increases brain ROS production and mitochondrial free radical leak.

Both mitochondrial dysfunction and oxidative stress are key events during stroke, suggesting that THC might increase patient's vulnerability to stroke and that further investigations would be helpful to determine whether mitochondrial protection and antioxidants might decrease THC-related neuronal damage in cannabis-induced stroke. https://www.ncbi.nlm.nih.gov/pmc/ar...n maximal,and mitochondrial free radical leak.
 

Captante

Lifer
Oct 20, 2003
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First thing I always do with an article like this is look at the publication date and the second is take a look at any possible "motivation" for a biased conclusion from the folks conducting the research.

The second thing is to both read and UNDERSTAND what I'm reading. ;)

Per the linked article:


"But after researchers adjusted for other factors that affect stroke risk, such as age, high blood pressure, high cholesterol, sickle cell disease, obesity, diabetes, smoking and heart conditions, there was no link between recent cannabis use and either an increased or decreased risk of stroke."


Having said that, I have zero doubt that smoking ANYTHING regularly can increase the risk of a person having a stroke as doing so reduces the blood's ability to carry oxygen putting strain on the circulatory-system.
 

IGBT

Lifer
Jul 16, 2001
17,967
140
106
First thing I always do with an article like this is look at the publication date and the second is take a look at any possible "motivation" for a biased conclusion from the folks conducting the research.

The second thing is to both read and UNDERSTAND what I'm reading. ;)

Per the linked article:


"But after researchers adjusted for other factors that affect stroke risk, such as age, high blood pressure, high cholesterol, sickle cell disease, obesity, diabetes, smoking and heart conditions, there was no link between recent cannabis use and either an increased or decreased risk of stroke."


Having said that, I have zero doubt that smoking ANYTHING regularly can increase the risk of a person having a stroke as doing so reduces the blood's ability to carry oxygen putting strain on the circulatory-system.
The article is still being used in many scientific research discussions having anything to do with mitochondrial disfunction...which is what caught my eye..I was researching mitochondrial disfunction in metabolic / autoimmune disease and similar i.e. diabetes.. Rheumatoid Arthritis...horrible disease with no good treatment options...
 
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Captante

Lifer
Oct 20, 2003
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The article is still being used in many scientific research discussions having anything to do with mitochondrial disfunction.

Discouraging that sort of thing, isn't it? :astonished:

Many years ago when I got heavily into collecting invertebrates (tarantulas, giant centipedes etc) I was completely shocked at the amount of pure unadulterated bull$hit-science there was in the hobby based purely on 40-50 year old (and discredited) "research".

Unfortunately any useful and credible study of the effects of weed on pretty much anything have been suppressed by it STILL inexplicably being listed as a "schedule 1" narcotic by our "imperious leaders" ROTFL. (making funding a tall order)

:rolleyes:
 
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IGBT

Lifer
Jul 16, 2001
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Discouraging that sort of thing, isn't it? :astonished:

Many years ago when I got heavily into collecting invertebrates (tarantulas, giant centipedes etc) I was completely shocked at the amount of pure unadulterated bull$hit-science there was in the hobby based purely on 40-50 year old (and discredited) "research".

Unfortunately any useful and credible study of the effects of weed on pretty much anything have been suppressed by it STILL inexplicably being listed as a "schedule 1" narcotic by our "imperious leaders" ROTFL. (making funding a tall order)

:rolleyes:
And that's very disturbing i.e. "schedule 1" narcotic. All the "political opportunities" the democrats let slip thru their hands and nothing has changed in that regard...screwing up research and prudent and reasonable policy. Unconscionable...
 

IGBT

Lifer
Jul 16, 2001
17,967
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mitochondria is the powerhouse of the cell
"The classic role of mitochondria is oxidative phosphorylation, which generates ATP by utilizing the energy released during the oxidation of the food we eat. ATP is used in turn as the primary energy source for most biochemical and physiological processes, such as growth, movement and homeostasis."...https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321783/#:~:text=The%20classic%20role%20of%20mitochondria,as%20growth%2C%20movement%20and%20homeostasis.
 

GodisanAtheist

Diamond Member
Nov 16, 2006
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Rule of thumb:

Weed while the brain is developing (~25 years of age) no way stay away.

Weed once the brain has matured and becomes progressively more vulnerable to diseases of age (~50 or so) a weed a day keeps the neurologist at bay.
 

brianmanahan

Lifer
Sep 2, 2006
24,563
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Rule of thumb:

Weed while the brain is developing (~25 years of age) no way stay away.

Weed once the brain has matured and becomes progressively more vulnerable to diseases of age (~50 or so) a weed a day keeps the neurologist at bay.

willie and snoop might live forever
 

mindless1

Diamond Member
Aug 11, 2001
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Meh, I'm not advocating that everyone start smoking weed to avoid a stroke, but seems to me that the associated reduction in blood pressure (unless you're prone to anxiety attacks anyway and maybe even more so then) would trump any other factors. Heh... except I'm not allowed to use that word or else, raises peoples' blood pressure lol.

Anyway, I skimmed over the linked article and a couple of things stand out. I did not read it carefully, not that important to me.

1) Young adults that smoke pot, likely have other risky behaviors. I don't mean to start arguments with pot smokers, but on average, yeah that is sadly the case for the youth engaging in it. For example stimulant use and poor diet.

2) Non-stimulant, psychoactive drug testing done on rats, or other lower animals is the worst kind of way to test for something like inducing a stroke, because their pea brains can't process causation, what is happening to them, while humans SEEK what is happening to them.

Big difference. If I smoked a joint to get high, I expect that. If I'm just minding my own business, never ingested THC in my life, and WHAM I'm stoned out of my mind (like if someone spiked a brownie) without ever experiencing that before, yeah it's going to be a massive blood pressure raising event.

They needed some controls. Set up a group of mice, who ate a little THC with some food treat, so they associated the buzz with pleasure. Get them used to it, and THEN run the comparison experiment.

Even then, it doesn't seem quite right to compare for something related to blood pressure, because it's a completely different scenario, being a rat in a lab being experimented on, compared to humans. In worst case. humans subject to addictive habits, will use the intoxication as a coping mechanism where there was an expectation of an escapism stress reduction, while with the rats, all they can really process is that what little of their instincts that they have that are relevant to survival of this science experiment, are now compromised.

That's about as far as I can project myself into the mind of a stoned rat. Because not stoned. :)

Dysfunction and oxidative stress? I think it is fair to state that any psychoactive substance would cause an increase, IF all else where equal. At the same time, all else isn't equal and it, as well as any other study that properly isolates a factor, unfortunately can't also de-isolate the relevance of that factor.

I'm suggesting that human THC consumption, has far less relevance to strokes than most other factors. like, if you wanted to, you could probably find a correlation to # of potholes on your local roads and tie that to strokes too.

Unsubscribed, I don't have sufficient interest in the topic to waste time arguing. Take that however you will.
 
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