The biggest weight savings that effect speed is in the wheels. The further out you go on the wheels, the more the weight savings will be felt.
It's like the flywheel of a car. The lighter the flywheel the less energy it takes to get it spinning, and the less energy it takes to STOP it.
Lighter rims, lighter tires, lighter tubes, less spokes, alloy nipples, and fewer crosses in the lace pattern.
The avarage wheel uses a 3 cross pattern. The fewer crosses you use the shorter the spoke will be = less weight.
You can go 3X 2X 1X or radial (No crosses) I use radial on my road bikes front wheel and a half radial (Non drive side) on the rear.
BTW: I work in a shop and build SWEEET wheel sets, if you want a wheel set built, PM me!