I didn't realize such a simple question would turn into an argument. Anyway....
On the MSI K8N Neo Platinum, SATA 3&4 are run off the chipset, whereas 1&2 are run off a seperate Marvell chip, which is NOT locked. A 5mhz overclock will cause the disk(s) on 1&2 to go undetected and in most cases corrupt them. If you don't believe me, search the MSI tech forums yourself. As far as I know, this is the case with ALL NF3 boards, it's just not common knowledge because the number of people with 3 serial drives is very small.
Now back to the original question...will there be any issues with the board to card switch before I spend $40 to attempt it?