What makes me think we could save money on doing it, is because if you cut the energy of the chip in 1/2, you cut the energy needed for airconditining and crap to 1/4, since generally you get a 2/1 ratio. Whether or not it's worthit, I don't know. I don't know for sure the efficencies of super conducters in circuitry.
I do know that with crystal clear lines (super conductors are always 100% efficnent) you could run them on ultra low voltage (Because not much power is needed to distinguish between 0 and 1, if you're using traditional electronics) and josephson junctions are hard to build so it might be easier just to bring the temperature of traditional conductors down to that level.
But the thing that intrigues me is that generally semiconductor performance goes up as temperature goes down. It might make it possible to squeze as much processing power out of 1 chip as you might get out of 4 in the first place. Super high frequencies, lower power (Less voltage), etc.. would equal one mean super computer.