Since you like Skyrim, there is always Fallout 3/New Vegas/4. Not the kind of futuristic sci-fi like Mass effect.
The Shadow Run series (+Dragon Fall & Hong Kong) are a solid cyberpunk set of RPGs.
You also have Deus Ex series, notably the newer Human Revolution and Mankind Divided, although those are also more cyberpunk than futurism.
That's the thing about the ME series, it's fairly unique for what it is.