kitkat22
Golden Member
Nakedfrog and I had made a post on national transgender visibility day. Since about that time, I have laid low but I made the decision to transition, change my name, markers, etc. Of course, as a consequence of transitioning, I have a huge target on my back, especially since I am a practicing physician. Many of my friends and family ask, "has it been worth it?" My answer is a resounding, "yes." The thing I sincerely wish, and I mean truly wish, is people to see the before and after in my well-being. Having gender dysphoria sucks. About this time as well, I decided to invest in a whole genome sequencing series from nebula.org. I was curious if there was any obvious genetic links with me. I originally submitted the test in Mar/Apr of 2022 and finally got the results last week. (I had to resubmit a sample.)
Turns out, I have a gene variant/mutation associated with intersex conditions on the FGFR1 gene. There were some others, but this one seems to make the most sense of the origin of the gender dysphoria. It's also associated with various malignancies (boooooo!). I was not born intersex but interestingly enough there is additional evidence pointing to this mutation. My lipid/cholesterol profile is unusual and FGFR1 is partly responsible for lipid homeostasis.
Now, I will be a good physician/geneticist and let you know this isn't foolproof. Because I wasn't born "intersex" it's really hard to prove this is the true gene. Like I said, there were about 3 other potential targets of interest. However, the FGFR1 mutation is the most likely and plausible.
Of further interest, nebula has a database of over 100 genes associated with sex reversal or intersex conditions. Just let that sink in - there are over ONE HUNDRED of our 20,000 genes that directly affect our sexual development. Not just the Y chromosome, not just the SRY or SOX9 gene but a collection of documented and medically proven and journal reviewed fact.
So, let's take a look at this legislation -
1) I have a genetic or chromosomal abnormality, but I don't the exclusion part of the "typical" definition of male or female- and I am going to say - who gets to decide? What does typical mean?
2) I might be able to be in the exclusion category by a medical professional in part 3-a-B
So my genetics predisposes me to gender dysphoria and if I was a kid in Texas, I would not get treatment. As a matter of fact, my parents (who support me) would end up in jail as a consequence. Talk about a perfect opportunity for a child to have depression, anxiety, PTSD and a severe suicidal risk. This law is going to go so well, I can tell /s
