cytg111
Lifer
- Mar 17, 2008
- 23,210
- 12,854
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Hmm, it might be. It's a complicated subject and the thing is, I rather agree with boomerang and his comment. Genetic testing (which is possible as early as the 8-cell stage) has certainly tossed a major whammy into the ethics issue here. I don't have the numbers on hand or anything, but I recall many years ago when I was considering going into genetic counseling, that aborting fetuses with Trisomy 21 is, rather unsurprisingly, quite common. That was 10 years ago when I think the only other effective genetic screen you could run was for Cystic Fibrosis.
I don't think this is a simple issue where there is a solid "yes this is the right decision for you and humanity" or "no, it is absolutely monstrous." I think the answer can be both, for the same couple and for different reasons. Obviously plenty of kids born with Downs syndrome can lead rather happy, productive lives. Parents love their kids...but at the same time, a young couple with such a fetus probably have no idea what kind of commitment that means: financially, emotionally, energy--a complete lifestyle change that was never in the cards. Things happen between parents they never thought possible: One blames the other for the horrible genetic defect that has destroyed their child's life and wrecked their family. Yes, it happens, and if one understands human nature, these kind of awful thoughts occur when you cast about looking for explanations that don't really exist. So, is it better to decide to abort if you absolutely know you can't raise this kid and give them a good life? Maybe.
as for genetically-engineering away these awful problems....I find that nature has some clever ways of reducing an accumulation of lethal genes that can wreak havoc on populations. Spontaneous abortions and miscarriages happen all the time...but we don't realize it because so few couples really advertise these things. It's a stigma. A developing embryo could have all sorts of supposed problems that are, now, easy to see and target, but looking at one or two of them, you're only seeing 1% of the picture. What if we manage to knockout something like ALS or a nasty gene with a high probability of cardiac hypertrophy, et al? I bet the presence of just some of these issues is an indicator for potentially others. You might be able to target and eliminate one dastardly gene, but leave the embryo viable to come to term with a host of others that never would have manifest.
And as Boomerang mentioned, say we were able to do an embryonic screen for ALS (I don't think that is possible yet...is it?), then what if Hawking's parents had made that decision and this world would have existed without him? I know it's something of a weak thought experiment because the world is simply what it is, the result of natural process generally beyond our control and a cascade of decisions made by generations upon generations, and it is almost certainly true that another physicist would have made the same discoveries (It is commonly accepted that great discoveries and inventions are as much, if not more a product of the zeitgeist in which the individual works, not a singular, unique genius--hell, the steam engine was invented a handful of times, over generations, long before Watt came along)...but the point is that an individual's worth isn't simply their ability to contribute in standard, societal-defined ways.
I think alot of your reservations is getting leapfrogged by technology, I fully expect the future of first world children to be engineered rather than by two strains of DNA randomly spliced together for constructs of natural selection to give a thumbs up or thumbs down over 50-100 years. Speaking of natural selection, we are in agreement that it was effectively nullified the second we decided to take care of our weak and sickly right? If we are to move the genepool forward today there is only one way to do it; edit the code (or bomb us back to sticks and stones).
For growing new humans I see genome editing/designing as an inevitable part of our future for the simple reason that if we dont do it we will at the loosing end of that natural selection equation. It would be like Russia having the nuke and we wouldnt.. and Russia pressed the button.
This is the bottom line, for each generation currently born under first world standards we loose a little functional DNA. We fade away, little by little, generation by generation. Eggs and Sperms dont form until later in the pregnancy, lots of time for DNA to shred and even then there is the odd chance of background radiation knocking one of those "Spermatogonial stem cells" out of wack.
Unless the genes are assoicated with core functionality of being able to go to term I dont see how or why it should result in spontanious abortion, if it is indeed the case as you say with Downs I expect, no I know , that that extra chromosome also codes for features that disrupts the whole biomechanical process that is the pregnancy.as for genetically-engineering away these awful problems....I find that nature has some clever ways of reducing an accumulation of lethal genes that can wreak havoc on populations. Spontaneous abortions and miscarriages happen all the time...but we don't realize it because so few couples really advertise these things. It's a stigma.
That might be. It may also not be. Not knowing. Is that gonna stop us or do we march on?A developing embryo could have all sorts of supposed problems that are, now, easy to see and target, but looking at one or two of them, you're only seeing 1% of the picture. What if we manage to knockout something like ALS or a nasty gene with a high probability of cardiac hypertrophy, et al? I bet the presence of just some of these issues is an indicator for potentially others. You might be able to target and eliminate one dastardly gene, but leave the embryo viable to come to term with a host of others that never would have manifest.
I think we should be careful of mixing quantitative considerations with qualitative, ie. using a qualitative measure to conclude something on behalf of something inherently quantitative. Stephen Hawking was most certainly a gift to mankind and not strapped to that chair who knows he may not have had the focus to experience the universe like he did, had we fixed him in the womb. Who knows? I do know that persons with downs do not fit into the social structures we have build for our selves and I also know that persons with downs is an evolutionary dead end, I know that persons with Downs will require many more resources than said persons is capable of giving back and I know that persons with Downs is a big stress on the parents and their relationships, I know that many persons with Downs end up living miserable lives.And as Boomerang mentioned, say we were able to do an embryonic screen for ALS (I don't think that is possible yet...is it?), then what if Hawking's parents had made that decision and this world would have existed without him? I know it's something of a weak thought experiment because the world is simply what it is, the result of natural process generally beyond our control and a cascade of decisions made by generations upon generations, and it is almost certainly true that another physicist would have made the same discoveries (It is commonly accepted that great discoveries and inventions are as much, if not more a product of the zeitgeist in which the individual works, not a singular, unique genius--hell, the steam engine was invented a handful of times, over generations, long before Watt came along)...but the point is that an individual's worth isn't simply their ability to contribute in standard, societal-defined ways.
I fully embrace the future of coding, programming language of the future : ACGT.