The lack of control over memory divider is a problem. I hope they fix it with a bios revision. I hope it is not a limitation of the nforce4 chipset and thus all nforce4 boards.
On the PCI locks question I can't say, as I don't have any PCI cards in my rig. Anything else run on the PCI bus? I can say that the PCI-E lock work's perfectly, as well as the SATA and IDE drives and USB devices. I have 2 optical drive and 1 hard drive on the IDE channels and 2 SATA raptors raid0 on the nvraid controller and several USB devices, and have had the FSB up to 291mhz with no stability issues.
Overall a very nice stable board with tons of features. And a decent(not great) overclocker
But for those who demand more flexibility in O/C ing, and those wanting to run two 6800gt or Ultras, I would say wait a few bios revisions and see if they get the problems/limitations ironed out. Or see what the other SLI motherboards will offer.
If they address the memory divider thing with a bios revision, I'll be a happy camper. As for the issues with high end VGA cards, I'll leave that to the suckers

(nice people) who would/can spend $1000 on graphics cards