A single file that is 160GB in size? Wow, that's one hell of a database, man! Sounds like an Exchange database or something like that. I have no single file at home that big. I do have approximately 800GB of mixed data; everything from thousands of 5MB pictures to images of every piece of software I own. I appreciate you sharing your personal experience, Emulex, but I don't have as much data as you to back up. At least not at home, which is where this box will be.

800GB is not a lot of data for a business, but at HOME, it's basically the digital repository of my life. All my email dating back to 1996 or so. Letters I wrote to family and friends, etc. It's priceless to me.
My only OS choices (not doing Linux...don't know enough about it to ensure my data is safe) are XP32, W2K3_32R2 or W2K3_64R2. I own legal copies of them. I own a copy of W764, but it's in use on my gaming/main computer.
I'm very familiar w/both XP and W2K3. If it were a daily use/do all computer it would be XP hands down. But this will be a headless box filling a true file server/backup role, managed via Remote Desktop. After the initial setup/patching, I don't want to do anything with it. I.E. a few months b/t reboots is what I'm looking for. W2K3 is where it's at.