Scientists Developing Obesity Vaccine

Page 2 - Seeking answers? Join the AnandTech community: where nearly half-a-million members share solutions and discuss the latest tech.

Amused

Elite Member
Apr 14, 2001
57,481
20,004
146
Originally posted by: Legend
Originally posted by: Amused
Originally posted by: Legend
Vaccine?

I think they mean fat loss supplement injection.

Actually, if you read the article a one time treatment turns an "easy gainer" into a "hard gainer" by increasing their metabolism long term.

This immune reaction apparently had effects on the animals' metabolism. Despite having free access to food and eating as much as their unvaccinated mates, the immunized rats gained less weight and boasted leaner, less flabby physiques.

That the weight effects came without diet changes was a surprise, Janda said. It means that the ghrelin vaccine acted on metabolism, and not appetite, he explained.

"They were eating the same, but still losing weight -- which is pretty cool."

What I meant is that vaccine usually implies a virus or pathogen. Implying that obesity is a disease. This is potentially a good thing for the few % that have genetical dispositions.

The fact that there are "hard gainers" and "easy gainers" means that obesity within a given environment IS a genetic predisposition.
 

Legend

Platinum Member
Apr 21, 2005
2,254
1
0
Originally posted by: xtknight
What about eating unhealthy stuff? You're still going to get all the cholesterol and trans fat even if you don't get the extra flabs. This is just as bad a health risk as obesity itself.

I'm fully aware that a large number of people have trouble due to genetic issues, but the majority, or 80%? I just can't believe that.

LOL, looks like amused is saying that 80% is genetic given an environment full of twinkies, french fries, mac and cheese, bottles of soda a day. Can't argue with that.
 

Amused

Elite Member
Apr 14, 2001
57,481
20,004
146
Originally posted by: Legend
Originally posted by: xtknight
What about eating unhealthy stuff? You're still going to get all the cholesterol and trans fat even if you don't get the extra flabs. This is just as bad a health risk as obesity itself.

I'm fully aware that a large number of people have trouble due to genetic issues, but the majority, or 80%? I just can't believe that.

LOL, looks like amused is saying that 80% is genetic given an environment full of twinkies, french fries, mac and cheese, bottles of soda a day. Can't argue with that.

Explain why a significant percentage of the population can eat whatever they want, and lead sedentary lives and never become overweight?
 

xtknight

Elite Member
Oct 15, 2004
12,974
0
71
Originally posted by: Amused
Explain why a significant percentage of the population can eat whatever they want, and lead sedentary lives and never become overweight?

I don't think a significant percentage can. A few may be blessed with a high metabolism, but lots of people who eat lots of junk food also exercise or do something during the day.
 

Thraxen

Diamond Member
Dec 3, 2001
4,683
1
81
People would just use a vaccine like this as an excuse to eat more and still be fat. And how does this effect things like cholesterol? Seems to me people will simply have the illusion of being in shape and still be falling over dead from heart attacks.
 
Feb 19, 2001
20,155
23
81
I believe we should just have reverse handicapped spots, and make the obese people park far away so they can walk further when they need to go somewhere.
 

Legend

Platinum Member
Apr 21, 2005
2,254
1
0
Originally posted by: Amused
Originally posted by: Legend
Originally posted by: xtknight
What about eating unhealthy stuff? You're still going to get all the cholesterol and trans fat even if you don't get the extra flabs. This is just as bad a health risk as obesity itself.

I'm fully aware that a large number of people have trouble due to genetic issues, but the majority, or 80%? I just can't believe that.

LOL, looks like amused is saying that 80% is genetic given an environment full of twinkies, french fries, mac and cheese, bottles of soda a day. Can't argue with that.

Explain why a significant percentage of the population can eat whatever they want, and lead sedentary lives and never become overweight?


I'm not arguing against that. But I don't think it's that significant. I've known people that graze on bad food. They stop when they need to. But not many. Some people that appear to eat whatever they want eventually get fat as they get older.

I think this is potentially great for the genetic few that can't be healthy with a healthy lifestyle. And for people on the grayscale it may help if it's their choice.

What I don't like is that this is a continuation of the laziness that is destroying America. The lack of personal responsibility in health, financials, politics, families, etc. Our birth is below maintenance level because people don't want to pay for children, our borders are flooding with foreign culuture that's not assimulating, too few people are aspiring to be scientists because that requires effort.
 

Amused

Elite Member
Apr 14, 2001
57,481
20,004
146
Originally posted by: xtknight
Originally posted by: Amused
Explain why a significant percentage of the population can eat whatever they want, and lead sedentary lives and never become overweight?

I don't think a significant percentage can. A few may be blessed with a high metabolism, but lots of people who eat lots of junk food also exercise or do something during the day.

You'd be wrong.

Again, I am amazed at the inability or unwillingness of people to admit this very simple fact. I'm wondering if it has something to do with the very young average age and lack of life experience, or if it's somehow tied to an irrational distaste for obesity, or what?

Look up "genetics +obesity" on Google. Every single valid link discusses what I am discussing here. That obesity and weight in general is a genetic predisposition that appears within a given environment.

Some people cannot gain much, if any weight no matter how hard they try. Go to ANY weight lifting forum to see endless threads about this. Others put on weight without even trying. On most weight lifting forums you have just as many people struggling to put on weight, as you have struggling to take off fat... often times more.
 

eLiu

Diamond Member
Jun 4, 2001
6,407
1
0
Mankind has gotten along for millenia without serious obesity problems.

Relying on medication to solve another artificial "problem" is ridiculous.
 

Thraxen

Diamond Member
Dec 3, 2001
4,683
1
81
Originally posted by: Amused

You'd be wrong.

Again, I am amazed at the inability or unwillingness of people to admit this very simple fact. I'm wondering if it has something to do with the very young average age and lack of life experience, or if it's somehow tied to an irrational distaste for obesity, or what?

Look up "genetics +obesity" on Google. Every single valid link discusses what I am discussing here. That obesity and weight in general is a genetic predisposition that appears within a given environment.

Some people cannot gain much, if any weight no matter how hard they try. Go to ANY weight lifting forum to see endless threads about this. Others put on weight without even trying.

I don't think it's a "significant percentage". I know maybe one or two people like that currently and have known a few more throughout my life. But I've known far, far, far more people that put on weight easily with poor eating. And I'm not really sure what weight lifting has to do with this. I can easily gain weight if I don't watch what I eat but I've never been able to pack on much muscle no matter how many hours I spent in the gym lifting weights. Two different things.

 

JohnCU

Banned
Dec 9, 2000
16,528
4
0
Originally posted by: eLiu
Mankind has gotten along for millenia without serious obesity problems.

Relying on medication to solve another artificial "problem" is ridiculous.

what other artificial problems are there?

and things are certainly different now than they were a millenia ago.
 

Amused

Elite Member
Apr 14, 2001
57,481
20,004
146
Originally posted by: eLiu
Mankind has gotten along for millenia without serious obesity problems.

Yes, we have. But mankind has never been faced with this environment we have created for ourselves. We have changed our environment, but not our bodies.

Again, obesity is caused by genetics AND environment. The genetics that allowed many to survive repeated famines and/or high physical workloads now works against them in an environment that allows sedentary living and endless, plentiful and cheap high quality/calorie foods.

And after over a decade of abject failure trying to tell people to use self control, we are left with two options: Change the environment, or change the bodies.
 

nakedfrog

No Lifer
Apr 3, 2001
63,194
19,539
136
Originally posted by: eLiu
Mankind has gotten along for millenia without serious obesity problems.

Relying on medication to solve another artificial "problem" is ridiculous.

The problem is real.
 

jlbenedict

Banned
Jul 10, 2005
3,724
0
0
Originally posted by: xtknight
Originally posted by: Amused
Explain why a significant percentage of the population can eat whatever they want, and lead sedentary lives and never become overweight?

I don't think a significant percentage can. A few may be blessed with a high metabolism, but lots of people who eat lots of junk food also exercise or do something during the day.

My brother-in-law eats nothing but pizza, hot pockets and donuts, works his 8 hour night job, comes home and sleeps until he has to go to work again..
and maintains a stick-like figure... I don't think that comes from working out..

 

Amused

Elite Member
Apr 14, 2001
57,481
20,004
146
Originally posted by: Thraxen
Originally posted by: Amused

You'd be wrong.

Again, I am amazed at the inability or unwillingness of people to admit this very simple fact. I'm wondering if it has something to do with the very young average age and lack of life experience, or if it's somehow tied to an irrational distaste for obesity, or what?

Look up "genetics +obesity" on Google. Every single valid link discusses what I am discussing here. That obesity and weight in general is a genetic predisposition that appears within a given environment.

Some people cannot gain much, if any weight no matter how hard they try. Go to ANY weight lifting forum to see endless threads about this. Others put on weight without even trying.

I don't think it's a "significant percentage". I know maybe one or two people like that currently and have known a few more throughout my life. But I've known far, far, far more people that put on weight easily with poor eating. And I'm not really sure what weight lifting has to do with this. I can easily gain weight if I don't watch what I eat but I've never been able to pack on much muscle no matter how many hours I spent in the gym lifting weights. Two different things.

Ever wonder why the best power lifters are people prone to severe obesity? Why are all the best power lifters saddled with extremely high body fat %s? How many champion power lifters have you seen who are cut with low body fat? None.

And if you gain weight easily and cannot pack on muscle it's not your genetics that are the problem, it's your lifting routine. Because yes, they are closely related.
 

xtknight

Elite Member
Oct 15, 2004
12,974
0
71
Originally posted by: jlbenedict
Originally posted by: xtknight
Originally posted by: Amused
Explain why a significant percentage of the population can eat whatever they want, and lead sedentary lives and never become overweight?

I don't think a significant percentage can. A few may be blessed with a high metabolism, but lots of people who eat lots of junk food also exercise or do something during the day.

My brother-in-law eats nothing but pizza, hot pockets and donuts, works his 8 hour night job, comes home and sleeps until he has to go to work again..
and maintains a stick-like figure... I don't think that comes from working out..

High metabolism. (see above)

Out of curiosity what does he do at his job? Is he standing?
 

Amused

Elite Member
Apr 14, 2001
57,481
20,004
146
Originally posted by: xtknight
Originally posted by: jlbenedict
Originally posted by: xtknight
Originally posted by: Amused
Explain why a significant percentage of the population can eat whatever they want, and lead sedentary lives and never become overweight?

I don't think a significant percentage can. A few may be blessed with a high metabolism, but lots of people who eat lots of junk food also exercise or do something during the day.

My brother-in-law eats nothing but pizza, hot pockets and donuts, works his 8 hour night job, comes home and sleeps until he has to go to work again..
and maintains a stick-like figure... I don't think that comes from working out..

High metabolism. (see above)

Out of curiosity what does he do at his job? Is he standing?

Wow... Standing 8 hours a day is the cure for all obesity?

I wonder when people will realize that not all bodies are the same. That the ability and propensity for obesity varies widely among people and is closely tied to genetics.
 

jlbenedict

Banned
Jul 10, 2005
3,724
0
0
Originally posted by: xtknight
Originally posted by: jlbenedict
Originally posted by: xtknight
Originally posted by: Amused
Explain why a significant percentage of the population can eat whatever they want, and lead sedentary lives and never become overweight?

I don't think a significant percentage can. A few may be blessed with a high metabolism, but lots of people who eat lots of junk food also exercise or do something during the day.

My brother-in-law eats nothing but pizza, hot pockets and donuts, works his 8 hour night job, comes home and sleeps until he has to go to work again..
and maintains a stick-like figure... I don't think that comes from working out..

High metabolism. (see above)

Out of curiosity what does he do at his job? Is he standing?

I think he is just a machine operator of some sort.. the place fabricates car parts for GM



 

Amused

Elite Member
Apr 14, 2001
57,481
20,004
146
OK, if this doen't convince you guys, nothing will:

http://www.ncbi.nlm.nih.gov/entrez/quer...PubMed&list_uids=8452057&dopt=Abstract

Many here have said fat people have fat children because of learned behavior.

This study flatly shows that to be incorrect. Fat people have fat children because of genetics.

How was this found out? A Danish study following adopted children born to obese parents and raised in average to thin families and vice versa. It shows that genetics, and not learned behavior controls the propensity for obesity.

You can argue against this all day long, but you'd only lose. It's but one of many studies showing the same thing.

A number of studies, including the Danish adoption study, have shown that, in adults, the familial resemblance of obesity, as measured by the body mass index (weight in kg/(height in m)2), is mainly due to genes. The body mass index may reflect both fat and fat-free body mass. In this further analysis of the Danish adoption study, the degree of obesity was assessed by a silhouette score. There was a significant relationship in scores between the adult adoptees and their biological mothers and between the adoptees and their biological full siblings reared by the biological parents. Weaker, nonsignificant associations were found for the biological fathers and for the maternal and paternal half-siblings. There were no relationships in silhouette scoring between adoptees and adoptive parents. The results confirm the results of our previous analysis of body mass index. We conclude that human obesity is under genetic control, whereas the childhood family environment has little, if any, influence on obesity in adults. It is an important task for future research to identify the genes involved.
 

Thraxen

Diamond Member
Dec 3, 2001
4,683
1
81
Originally posted by: Amused
[Ever wonder why the best power lifters are people prone to severe obesity? Why are all the best power lifters saddled with extremely high body fat %s? How many champion power lifters have you seen who are cut with low body fat? None.

And if you gain weight easily and cannot pack on muscle it's not your genetics that are the problem, it's your lifting routine. Because yes, they are closely related.

But aren't you making the same sort of sweeping generalizations that you are telling other people not to do? Sorry, I went to a gym for a while and was doing a routine with a friend that was designed by one of their instructors. I got stronger, but added very little mass. Yet I can add and drop weight in fats stores very quickly (well, add much faster than remove... lol). I've been this way my entire life. It may be true that many power lifters can can also easily pack on fat, but I know from experience that the abilty to pack on fat != the ability to pack on muscle.
 

jlbenedict

Banned
Jul 10, 2005
3,724
0
0
Originally posted by: Amused
OK, if this doen't convince you guys, nothing will:

http://www.ncbi.nlm.nih.gov/entrez/quer...PubMed&list_uids=8452057&dopt=Abstract

Many here have said fat people have fat children because of learned behavior.

This study flatly shows that to be incorrect. Fat people have fat children because of genetics.

How was this found out? A Danish study following adopted children born to obese parents and raised in average to thin families and vice versa. It shows that genetics, and not learned behavior controls the propensity for obesity.

You can argue against this all day long, but you'd only lose. It's but one of many studies showing the same thing.

A number of studies, including the Danish adoption study, have shown that, in adults, the familial resemblance of obesity, as measured by the body mass index (weight in kg/(height in m)2), is mainly due to genes. The body mass index may reflect both fat and fat-free body mass. In this further analysis of the Danish adoption study, the degree of obesity was assessed by a silhouette score. There was a significant relationship in scores between the adult adoptees and their biological mothers and between the adoptees and their biological full siblings reared by the biological parents. Weaker, nonsignificant associations were found for the biological fathers and for the maternal and paternal half-siblings. There were no relationships in silhouette scoring between adoptees and adoptive parents. The results confirm the results of our previous analysis of body mass index. We conclude that human obesity is under genetic control, whereas the childhood family environment has little, if any, influence on obesity in adults. It is an important task for future research to identify the genes involved.

Thanks for posting that. I couldn't open that link here at work. It came up in my search on Google also.

I came across another article where research discovered the "clock" gene could be a factor in weight gain.



 

xtknight

Elite Member
Oct 15, 2004
12,974
0
71
The main thing that's worrying is people getting a false sense of healthiness by being able to eat what they want and having a drug thwart only the visible effect of it. If genetics is the main cause, so be it I guess. But this is far from a perfect solution. They will still get the cholesterol, and have high blood pressure, and high triglycerides from eating unhealthy. If I'm missing something then be sure to let me know. If people use this "vaccine" to eat healthy then I think it's the best thing to happen to medicine in the past few years. They will not have the extra body fat to lug around and their insides can be in decent condition too.
 

Amused

Elite Member
Apr 14, 2001
57,481
20,004
146
Originally posted by: Thraxen
Originally posted by: Amused
[Ever wonder why the best power lifters are people prone to severe obesity? Why are all the best power lifters saddled with extremely high body fat %s? How many champion power lifters have you seen who are cut with low body fat? None.

And if you gain weight easily and cannot pack on muscle it's not your genetics that are the problem, it's your lifting routine. Because yes, they are closely related.

But aren't you making the same sort of sweeping generalizations that you are telling other people not to do? Sorry, I went to a gym for a while and was doing a routine with a friend that was designed by one of their instructors. I got stronger, but added very little mass. Yet I can add and drop weight in fats stores very quickly (well, add much faster that remove... lol). I've been this way my entire life. It may be true that many power lifters can can also easily pack on fat, but I know from experience that the abilty to pack on fat != the ability to pack on muscle.

How about you tell me what your weight lifting routine was like?
 

SagaLore

Elite Member
Dec 18, 2001
24,036
21
81
This is very cool. BUT, I'm a little scared they're using the body's own immune system to attack a normal hormone that affects metabolism. Instead of a suppressor, this is actually an attacker. I have a feeling this is going to cause an "addiction", where as if someone taking this stopped, their metabolism would skyrocket fat production moreso than before.
 
May 31, 2001
15,326
2
0
In reference to a long-ago thread regarding obesity and exercise, wherein I was talking about obese people using powered shopping carts and you mentioned that there were those that may have become obese after sustaining an injury which severely limited their mobility, I think this would be a real boon for people in that category. Presuming it is developed to the point that it is safe and available for human use, of course.