Contrary to popular opinion, it is not only possible but essential with some motherboards. My Asus P4Pe has two SATA ports. They are enabled or disabled in BIOS, but combined with RAID. You can't have SATA w/o RAID on this mobo. So, it loads and runs the RAID menu before loading Windows, and with 1 HDD, it forces RAID 0. Technically, that is not an array, but it is the only way SATA ports can be enabled on this mobo.
So, that is how I run my data drive - an 80 GB single drive as "RAID 0."
If I do not use RAID, the SATA drive cannot be seen. In this case, performance is irrelevant.