From what I have read in many AGP 8x MoBo reviews, current applications and games do not even utilize the full 4x AGP bus yet. There is always the possibility for example, that some high end software like CAD or realtime 3d rendering programs may call for such bandwidth. But I haven't read anything like that for the average gamer and PC user. It's good to have an AGP 8x card though. That means that you can upgrade your 4x MoBo to an 8x MoBo later on and still have an up to date Vid card. So to answer your question to the best of my ability, no, you will not lose performance with a 4x MoBo and 8x vid card.
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