Not that much more different except you just deal with more records (A, MX, PTR, FTP, WWW, etc...).
MS DNS will do the job for you, just be sure to patch the OS well itself and always monitor traffic. Set-up a packet filter if need be and don't forget your firewall.
As your hosting customer base starts growing you can count on having more DOS attacks, script kiddies hitting you and a whole slew of other things coming your way. So it's better to be prepared for it right from the start. Always be vigilant and you'll be successful 🙂