While a clean install is always best, there is a very strong probability that it will work just fine. Just make sure to do a complete system backup before you try it. Also, if you have installed software like Adobe that itself uses activation, make sure to also deactivate that software before the swap. Then, once the swap is complete and everything is working, you can re-activate it.
It further wouldn't be a bad idea to create a Windows install media before you do the swap so that you will be able to run a startup repair if needed.
Windows has continued to evolve its ability to handle major hardware changes over time, and Windows 10 is the best yet in this regard. If it works as expected, you'll probably want to remove the Intel chipset drivers after the swap and install the most recent AMD drivers from the AMD website. Similarly, if you upgrade your video card, you'll want to update those drivers too.
One thing to be careful of - a major hardware change like this done on a system using an OEM Windows license will usually result in activation problems that may require purchase of a new Windows license. OTOH, if you have a retail Windows license it should activate just fine provided you aren't over the activation limit.