These 4 memory are manually configured to be same speed, same latency.And they are same in memory size. I think the asymmetric access is not the problem. Yeah the fast speed memory will definitely help my framerate. But for 70 bucks, performance to price ratio is not that good to me. I gonna save this for my next upgrade to ddr4 and new cpu several years later. Thank you manI think mixing and matching will cause bottlenecking due to asymmetric access. You should buy a 16GB kit of 2133, less than $70. It will be worth since it will raise your minimum frame rates and moving from 8GB to 16GB is a nice upgrade.