So I've seen two systems do this:
Core 2 Duo, 975X DFI Infinity running Vista 64 Ultimate - LAN connection just disappeared entirely from device manager. Reinstalling the DFI driver didn't work because the device manager doesn't exist. It says there's no LAN card. LAN existed in BIOS, and worked under Ubuntu and Linux, but it was completely missing in Vista. There's nothing with a "!" next to it in Device Manager - the LAN entry is just completely gone. This problem started back in Oct/Nov last year, and my solution was to add in a spare 100Mb PCI ethernet card.
Pentium M 770, AOpen i915Ga-HFS running XP Pro - LAN connection is in device manager, but the device falls off the network whenever I do anything with it. It loses it's IP and then infinitely retries over and over. Rebooting solves the problem briefly but as soon as the connection is used for anything more than just surfing the web, it dies again. The problem started in mid-Jan '09 and my solution for this was the same thing - I used my other spare 100Mb ethernet card. .
I don't think either of these are board issues, but I didn't feel like prowling around in the registry trying to figure them out. I upgraded the Core 2 Duo system to a Core i7 and everything has been happy with it. I wouldn't mind removing the network card from the XP machine, I'll try rolling back the network driver. I have automatic updates totally enabled on the XP machine - it's my home theater computer.