I was referring to the speed, and ease of booting off of eSATA compared to the USB drives... eSATA Will boot with anything, USB only with specific mobos and you have to make it into a USB boot drive (UGH) and then there are tweaks to do to the OS... a lot of pain. And eSATA IS MUCH faster.
MTBF is bull: 1.5 million hours = 171.23 YEARS
What you should concern yourself with is the write limit of SSD, the read limit, and the store limit.
Normally I would say to stay AWAY from any and all thumb drives as they do not have the quality of wear leveling (if they even HAVE wear leveling) that proper SSD have; thus for a home user a thumb drive will be ruined by an OS rather quickly.
BUT, as an OS drive on a SERVER you are basically just READING from it now and then (on the rare occasion that you reboot or update the server)... the life limit of SSDs is in WRITES only... so they should all last for essentially forever...
One cavet. After 10 years of NOT being written to, flash cells begin to lose stored data.
the intel X25 drives have a special algorithm that caps write speeds if needed to ENSURE they get 5 years. even without it, they should last a long long time, hundreds of years for most users due to how resilient they are... as an OS drive for a server it would be practically untouched.