I've also heard that some types of ram do not comingle very well...ram made by company x might not work well with ram made by company y. However, as for the 100/133, it will work fine...I used to have my old PIII setup like that with 256 at 100, 256 at 133 (planning ahead to upgrading mobo/cpu). The faster ram simply runs slower...
The speed difference is TOTALLY NOT NOTICEABLE!!! I am switching from 512 of PC-100 to 512 of PC-2100 (133MHz) DDRSDRAM...can't tell a damn difference under normal operation. Some large Photoshop files seem to benefit from the added speed...but not much else.