I wouldn't put this in to the perspective of what's "best" or "worst," because RAID-0 may be a great option for some, and not for others... Basically it's a question of RISK.
Keep in mind that Hard Drives fail with greataer frequency than other PC components due to their mechanical operation. In a single HD non RAID setup, if your hard disk fails, it fails and you loose your data. In RAID-0, you take two hard drives and combine them such that they're treated as one. In this setup, when data is written to the hard disks, the data is split by the RAID controller, and half is written to HD1 and the other half is written to HD2. Therefore, if one hard drive goes bad, you loose your data across both.
RAID-1 takes two hard drives and mirrors the data between them. This provides for better safety / lower risk vs. a single non raided drive, because if one drive goes bad, you can jump to the second drive which is just a copy of the data on the first drive.
More advanced RAID combinations allow you to mix and match striping and mirroring across more than two drives. RAID 10 (or 0+1) takes four drives (or multiples of 2 thereof) and provides a combo RAID-0 RAID-1 solution. RAID-5 can give you a combo solution with three drives, using the third drive to hold parity information in case you need to restore from a drive failure.
Mark.