I'll bite. Yes, it can make a difference -- the 132 MB/s or so total bandwidth of the PCI bus risks being saturated by such devices, esp. with several drives or if you add a gigabit PCI card to the mix -- so I'd avoid PCI bus implementations.
The only downside is that you're tied to the MB / chipset vendor, whereas you might be able to take the card with you to another system. NForce 5-whatever will have RAID 5 support too. I'd want that, assuming it performs and shows compatibility by being able to up-convert NForce 4 RAID.
PCIe RAID cards (4x) would be another alternative.