3 22" screens at work. I use all the space they give me. At home I use a 24" IPS as a secondary to my 27" IPS primary. Two different resolutions, but It hasn't been an issue.
At work I use the three screens to easily manage several IBM iSeries, VM Clusters, Lotus Notes Servers, etc. At home I use the second screen a ton when I play EverQuest 2. The game is on one screen, and Browsers, Parsing applications, Chat windows, etc are on the second.
I even attach a 20" panel to my MS Surface Pro when I am at work for a second screen.
I can't live with just one anymore!