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Prince ... dead. RIP.

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I'm in the heroine or similar prescriptive camp. Easy to imagine a pain killer being prescribed to a 57 year old guy who moves around a lot on stage.
 
Prescription main peds, particularly if we are talking about opiates like Oxy, are among the very easiest drugs to OD on. So even if he never took illegal drugs, the possibility of an OD remains.
That or like Heath Ledger, a cocktail of prescription pain medication, a little over-the-counter pain medication, flu medication, couch syrup, etc. Pretty soon you slow down your body to the point that it stops.
 
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