I've played an American Strat but I've got a mexi-strat, a Gibson LP Studio, and a Schecter C-1 Plus w/EMG 81 and 60. To be comepletly honest my favorite out of them all is the Schecter, it's got a strat body with an LP sound? But in keeping with the question, between the American Strat and the Gibson LP, I'll go with the Gibson.