The updated chipset drivers are probably good to install. I assume you started with the chipset drivers from the DVD that came with the motherboard, yes? I used to have that board, and I seem to remember that the newer chipset drivers improved USB 3.0 support.
The Asus BIOS firmware seems to improve with each new version as they fix bugs, so that's probably worth doing, too. If you installed AI Suite from the DVD, you can update the firmware from Windows by downloading the new one, unzipping it, then pointing the AI Suite utility to the .CAP file. The "Update over the Web" option never works for me, so I do the download.
The LAN, audio, etc. drivers are all separate downloads, and are totally optional unless you want the latest and greatest.