It will usually depend on the video card being used. My Radeon 64mb VIVO works just fine with AGP 4X with a FSB of 165mhz, but my old GF2 GTS would quit around 160mhz FSB. The new GF3's seem to be even less tolerant of high FSB/AGP speeds, and I have heard you need to disable 4X to go much over ~150mhz...