Lots of benefits with NTFS, most of which have been mentioned already.
The only cons IMO are that its somewhat slower, but not noticeably so unless you have a very slow comp.
And like Castellan said, if you're dual booting with some 9x, you wont be able to access the NTFS drive from 9x.
If none of the above is a big deal to you, go with NTFS.