I also have the same issue with POE from time to time. It's like I just hit the pause button for 2-3 seconds and thats it, runs fine after that. I'm not sure what causes it and it's the only game that happens to. It's just like when your internet connection acts up except without the connection message on the screen. But other then that its very smooth and it only happens once. I've changed so much on my machine I don't know what causes it.... I just signed up to let you know your not alone. In fact a couple others listed this problem in the POE forums.
My guess is either data is loading from/to somewhere not as efficiently as it should be, or some setting (bios or graphic card) isn't set right. Other then that it runs great im using all highest details @ 1280x1024 4xAA/8xAF (Yes my machine can handle this). I'm even looking towards SP2, i've had a couple of issues so far with it and wouldn't suprise me if its at fault. I've played POE for awhile and it just started happening. But like I said i've changed too much to narrow it down to one thing, and its the only game that does this and it's really not that bad.
My guess is either data is loading from/to somewhere not as efficiently as it should be, or some setting (bios or graphic card) isn't set right. Other then that it runs great im using all highest details @ 1280x1024 4xAA/8xAF (Yes my machine can handle this). I'm even looking towards SP2, i've had a couple of issues so far with it and wouldn't suprise me if its at fault. I've played POE for awhile and it just started happening. But like I said i've changed too much to narrow it down to one thing, and its the only game that does this and it's really not that bad.