Well, a 400MHz (200MHz DDR) memory clock certainly won't hurt anything, but you have to remember that most systems perform optimally when the FSB and memory clock are synchronous. If you have an AMD processor and overclock the FSB to 200MHz then running your memory at 200MHz DDR would be great, but if you leave the FSB at its default speed of 133MHz or 166MHz then running your memory at 200MHz DDR won't be much of an improvement than running PC2100 (133MHz DDR) or PC2700 (166MHz DDR) RAM.