I have the Epox 8RDA and Win98se. All seems good so far. The only real problem I have noticed is BF1942 with the on-board sound seems like it is being rendered at fast forward, which makes the game unplayable. Someone said to download the Realtek ACL650 (not sure if that's right) drivers from Realtek, but when I move my USB mouse around I hear static, and there is a high pitched whine and other noises that go on in the back-ground at even relatively low volume levels.
All other games I have tried work great so far, and the 2-channel sound is very good IMHO.