It looks like you have an always-on connection, so you can just check the box labeled "Auto Transmit" and then press "Save Config". Then, when you finish crunching a work unit, SETI Driver will automatically upload the results and download a new one.
I would guess your rig can do 4-5 work units per day. So, with a cache of 10, you'd be good for about 2 days if your internet service went out or the Berkeley servers were down. Most people like having 3 days worth of work units cached just in case there's an outage. With some of the problems lately with the Berkeley servers and OK's proxy, more people are upping the cache to a week's worth, just in case.
So, I'd increase the cache by a few work units. Just make sure to press "Save Config" after changing any options. 🙂